Congenital SPCA deficiency: a hitherto unrecognized coagulation defect with hemorrhage rectified by serum and serum fractions.

Congenital Deficiency of Proconvertin : A Clinical

With the technical assistance of Mary Jane Patch D ESPITE THE FACT that SOIll 65 cases of congenital deficiency of proconvertin have been reported, there still remains considerable confusion regarding the nature of the defect, its effect on the coagulation mechanism and the classification of these cases. It is the generally accepted 2 that proconvertin ( factor VII, SPCA, stable factor, co-thro...

Seventeen Alpha-Hydroxylase Deficiency Associated with Absent Gonads and Myelolipoma: A Case Report and Review of Literature

Congenital adrenal hyperplasia comprises a group of disorders resulting from defects in enzymes required for the synthesis of cortisol. The clinical presentation depends on the specific enzyme defect. We report a rare case of congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency. A 26-year-old female patient referred with hypertension and hypokalemia. She also had primary amenor...

Evaluation of Brain Natriuretic Peptide, Tumor Necrosis Factor and Interleukin-6 Plasma Levels in Infants and Children with Congenital Heart Disease

Background Congenital heart disease (CHD) is the most common cause of major congenital birth defect. The aim of this study was to investigate the association of CHD with serum levels of Tumor necrosis factor-α (TNFα), Interleukin 6 (IL-6), and B-type Natriuretic Peptide (BNP) in infant and children. Materials and Methods The present study was conducted in Heshmat heart hospital and 17 Shahrivar...

Plasma thromboplastin component (PTC), a hitherto unrecognized blood coagulation factor; case report of PTC deficiency.

Women’s Health & Gynecology

Factor XII, (Hageman factor) is a serine protease zymogen that, when activated, initiates the intrinsic pathway of blood coagulation. Patients with Factor XII deficiency do not have excessive bleeding tendency despite prolongation of the activated partial thromboplastin time (APTT) in their serum. Postpartum Hemorrhage (PPH) is a potentially fatal obstetric complication, and its presence in the...